"You'll make a nice test subject."
—Spoken during victory.
Albert Wesker is the main antagonist of the hit Capcom series Resident Evil/Biohazard and sworn enemy of Chris Redfield and Jill Valentine of S.T.A.R.S. He appears in Marvel vs. Capcom 3 carrying on his appearance from Resident Evil 5 (Biohazard 5).
Anyone who knows him will tell you that Wesker's true loyalty is power and how to gain more of it. A former Umbrella employee, he made many breakthroughs alongside his colleague William Birkin such as the G-virus and the Nemesis Parasite. He was eventually ordered by Umbrella to lure the S.T.A.R.S. team into the Spencer Estate, in order to test the newly created B.O.W.s that roamed the mansion. When Chris Redfield and Jill Valentine discovered his true motives, Wesker injects himself with a specially engineered virus and has the Tyrant attack him, which seemingly kills him.
It was later revealed that Wesker survived and made it out of the mansion shortly before it self-destructed. The virus he injected himself with gave him superhuman strength and speed, the only visible mutation on his body was his cat-like red eyes, which he hid behind dark sunglasses. Wesker left Umbrella shortly after and mostly stayed behind the scenes during the events of Raccoon City and its destruction. He began working for another secret organization against Umbrella. The organization's purpose was to cash in on some of Umbrella's research. His first mission was to Russia where he ran into his old friend Sergei Vladimir, an old Umbrella employee himself. Wesker was later sent to Rockfort Island, where he came across Chris Redfield again. After facing off with him in an Umbrella facility in Antarctica, Wesker escapes once again.
Weskers next move was to create a virus to release into the Earth's atmosphere. Teaming up with the beautiful Excella Gionne, he travels to Africa to access an old Umbrella facility in Kijuju. His actions attracted the attention of the BSAA and its agents Chris Redfield and Sheva Alomar. Although they were foiling his plans, Wesker managed to stay one step ahead of his enemies until they caught up with him at the airpad that housed his plane that would release Uroboros. After a battle around the plane and inside it, they crash landed in a volcano where Wesker allowed Uroboros to mutate him. In Wesker's last stand however he was defeated by his old enemy when they fired two rockets at him, killing him.
- He is the first official villain in the Capcom side to appear in MVC3, the second being Akuma.
- He was confirmed during the Tokyo Game Show 2010, along with Spider-Man, Tron Bonne and X-23.
- Wesker has an alternate color scheme that gives him a white suit and white coat (scientist getup, which also references a photo of him in a lab from Resident Evil) and a scheme that gives him white hair, blue coat, and a black undershirt (resembling Vergil). For Ultimate, he loses his Vergil alt. (since Vergil is in the game) and gets color schemes based off Gambit (sort of) and M. Bison, plus his pre-order DLC costume is his original S.T.A.R.S. uniform from Resident Evil 1.
- His character theme is a remix of "Winds of Madness", his boss theme in Resident Evil 5.
- His Level 3 Hyper is called Lost in Nightmares (a DLC mission set before the events of the game; the Spencer Mansion incident with Wesker, as seen in flashbacks throughout RE5). The final attack in that hyper (where he throws a rocket at the opponent) is based off of the second fight with him in 5, where Wesker would occasionally grab rockets and hurl them at Chris and Sheva once things started to heat up.
- His standing M (Panther Fang), standing H (a double-legged spin kick), and launcher attacks (Tiger Uppercut) are taken straight from his melee attacks in Resident Evil 5. The Cobra Strike and Ghost Butterfly specials also reference this, as do his ground throws (his Windfall) and his Mustang Kick (now a command throw).
- Wesker's Windfall and Panther Fang are the only two RE5 moves to be normal attacks, with the former being a throw and the latter being his standing M.
- Wesker shares the name of his Tiger Uppercut move with Street Fighter character Sagat. He also shares the move name Jaguar Kick with Adon, who is Sagat's apperentice and also is from Street Fighter.
- His Jaguar Dash and Tiger Knee are also taken from the fifth game—specifically, the the quick-time event where Wesker lunges at Chris at high-speeds, Chris blocks Wesker's Knee Cannon attack and retaliates with a fist to the face (knocking Wesker flat on his ass), only to then shake his hand in mild pain.
- Rhino Charge (his counter/reversal hyper) is another one of his melee attacks from 5, while his Phantom Dance could be seen as a souped-up Collide.
- Wesker has two attacks, Jaguar Kick and Tiger Uppercut, named after Adon and Sagat, respectively, from the Street Fighter series.
- One of his opening lines is "There against three, a reference to RE5, where Chris and Sheva face off against Wesker and Jill (his line there was "I think the odds are fair, two on two.")
- One of his winquotes references his infamous "COMPLETE GLOBAL SATURATION" line from RE5.
- Wesker's post battle quote "Now if you'll excuse me, I have a world to saturate..." also nods to this line, which has become the subject of an internet meme that even Wesker's voice actor, D.C. Douglas, got in on with several joke videos on his YouTube account. Playing as Wesker 100 times also unlocks a title called "Global Saturation!".
- Wesker brandishes his Beretta 92F Custom "Samurai Edge" handgun from his S.T.A.R.S. days. As in RE5, this is the only firearm he carries on his person.
- In Japanese, he is voiced by Jouji Nakata. In English, he's voiced by D.C. Douglas, who reprises his role as Wesker from Resident Evil 5.
- Strangely enough, Kirei Kotomine's purple streaks from his Zekken (Ending Fist) attack and other moves in Fate/unlimited codes resemble Wesker's streaks from his 2B/M, j.B/M, Cobra Strike, Ghost Butterfly, Phantom Dance, Rhino Charge, Windfall, Tiger Uppercut (5S and reversal version), Mustang Kick and Lost in Nightmares. Coincidentally, both are voiced by Jouji Nakata in Japanese, as he is well known for villain roles.
- Even more coincidentally, Capcom even licensed Fate/unlimited codes.
- His win pose shows him looking away from the camera, only to quickly turn back and grab the bottom of the screen, apparently strangling the cameraman and breaking the fourth wall.
- Albert Wesker is one of the sub-bosses at the end of story mode, powered by Galactus' cosmic powers, yet he only appears when playing as certain characters. Other sub bosses include (Cosmic) Doctor Doom, (Cosmic) Dormammu, and (Cosmic) Akuma.
- His Phantom Dance hyper-combo is called "Maximum Wesker" by the fans, due to looking similar to Spider-Man's Maximum Spider combo. It was even called such by Seth Killian while commenting on an MvC3 tournament multiple times.
- Deadpool makes a reference to this when he wins against Spider-Man in Ultimate MVC3. "Hey, did you know that Wesker guy stole your Maximum Spider move? You were doing that back in Marvel Super Heroes! So... Gonna go kick his ass? Can I watch?"
- Wesker's ending involves him capturing the weakened Marvel heroes after their battle with Galactus. He plans on injecting the Uroboros virus into their bodies and observe what happens. It is rumored to be a subtle reference to the Marvel Zombies comics.
- Another reference to the Marvel Zombies comics is one of Wesker's lines in his ending in UMvC3, where he says "... should yield zombies to truly... marvel."
- If one observes carefully, Wesker seems to be emitting a faint, smoky aura when he's standing still.
- If Wesker's sunglasses are destroyed during battle or removed upon performing Phantom Dance, pressing the taunt button will have Wesker put a new pair on. Wesker's shades can also be restored when he's tagged out, then tagged back in at a later time.
- Wesker has an interest in M.O.D.O.K's structure. He gives Jill orders to find him as a target which her pre-fight quote being "Target acquired", and after beating M.O.D.O.K himself, Wesker will say he's looking forward to "dissecting that ridiculously large brain of yours."
- Wesker was shown alongside Spider-Man, because they both were geniuses who were infected and got their super natural powers.
- If one looks closely during Wesker's Tiger Uppercut Reversal (L/A version), he'll lean backward if hit during his counter stance before hitting the opponent. This could be a possible nod to Neo from The Matrix, whom Wesker bears a resemblance to. Rhino Charge is another reference to The Matrix, borrowed from Agent Smith.