"Come on Six Machine! Six Cannon!"
Desperado is one of Viewtiful Joe's Hyper Combos. Six Machine appears with Joe's girlfriend Silvia riding on top of it. Joe then uses the cannon to fire a single, powerful laser blast at his opponent. Can be used in midair and also can hit OTG.
- Desperado activates much more quickly (practically instantly) than in Tatsunoko vs. Capcom, though the blast travels much more slower at a cost.
- This move is known as Six Cannon (シックスキャノン Shikkusu Kyanon) in the Japanese version of the game.
- Oddly, "Desperado" is the name of the guns that Sexy Silvia uses as a weapon, not the Six Cannon, which is used in the attack.